My Mother Died On Lexapro. Last March I Was Handed The Same Prescription. — Slow Mornings

My Mother Died On Lexapro — Stable Mood, Perfect Labs, And A Body That Quietly Fell Apart For Twelve Years. Last March I Was Handed The Same Prescription.

What I learned in the six months between sitting in that parking lot and writing this — and why I never filled it.
My mother in the last winter
My mother in the last winter. Twelve years on the medication. Stable mood. Perfect labs. She hadn't been out of the house in eight months.

My mother died on Lexapro.

Not from Lexapro. Her doctor was very clear about that, and so am I. She died of complications from twelve years of decline that nobody could explain. Heart, then liver, then a long final winter where she didn't get out of bed.

What I want to tell you is the part nobody at the funeral talked about.

My mother was, by every official measure, being well-managed. Her mood was stable. Her bloodwork was in the ranges her doctors wanted it in. Her medication chart was a perfect grid of taken-pills, every single morning at 7:00 AM, for twelve years. She had a little plastic organizer she would show me on Sundays — all seven slots empty, every week. "See? I'm doing everything right."

She was doing everything right.

And she still disappeared.

My mother before the prescription
My mother the summer before she started the Lexapro. This is the woman I want you to keep in your mind for the rest of this letter.

I'm writing this because six months ago I sat in my car in a parking lot in Bloomington, Indiana, holding a prescription for the same antidepressant my mother took for the last twelve years of her life. Lexapro. 10 milligrams. One pill, every morning. For the rest of my life, probably.

I had walked into the appointment because I had not gotten out of bed before 9 AM in four months. Because I had cried in my car twice that week for no reason I could identify. Because I had been gaining weight on 1,200 calories a day. Because I had stopped picking up the phone when my sister called. Because my husband had asked me, gently, one night in November, "are you still here?" and I had not known what to say.

The doctor was kind. She listened. She wrote the prescription. She said: "Given your family history, this is the responsible thing."

Family history.

That phrase sat in my chest like a small cold stone for the next four months.

Because my family history was a woman who took this exact medication every morning for twelve years, on a stable mood, while her body fell apart underneath her in slow motion, while six different doctors prescribed six different things for the symptoms her perfect mood was apparently not preventing, while she gained forty pounds eating less than her husband, while her hair fell out and she started wearing scarves indoors, while she stopped going to her book club and then to church and then to the kitchen, while she became a woman I did not recognize in a body that was being managed beautifully on paper.

Family history.

I took the prescription. Walked to my car. Sat there for a very long time.

I never filled it.

This is what happened in the six months between that morning in the parking lot and tonight, when I am writing this from a kitchen table in a house I have started inhabiting again. I want to write it carefully, because there is something in here I think other women — and other men — need to know.

March 15

Didn't fill it.

My husband asked why. I couldn't answer. I told him I needed a few days to think. He sat down on the bed next to me and put his hand on my back and didn't say anything for a long time, which is one of the things he does that makes me love him.

What I kept thinking about, lying in bed that night, was Mom's pill organizer.

She took it every single morning. 7:00 AM. Twelve years. Never missed a dose. Showed me the empty slots every week the way a child shows you a perfect spelling test.

And she would say, every family dinner, "My mood is good. The medication is working. I just feel a little tired."

By year three the tired was a fog she lived inside. By year five she had stopped going to her book club. By year seven she was wearing scarves and a hat indoors. By year ten she could not remember the name of her own grandson, my nephew, for a long ten seconds at his sixth birthday party.

The whole time her mood was stable.

The whole time the medication was working.

If the medication was working — if her mood was stable — why was she vanishing piece by piece while her doctor kept telling her she was doing well?

That question stayed with me. I could not put it down.

March 18

The nurse from the doctor's office called.

"You haven't picked up your prescription, Diane."

I said I needed more time.

"Your symptoms are significant. With your family history, this is the responsible thing to do. We don't want this to get worse."

I thanked her. I hung up. I sat at the kitchen table for forty minutes.

I kept thinking: my mother's mood scale was a 7 when she died. Stable. Well-managed. And she was a woman who had not been outside in eight months.

What's responsible is I don't want to end up like her.

March 22

I have gained sixteen pounds since November.

I have not changed what I eat. I have not stopped walking. I am, by any honest accounting, eating less than I was a year ago because I have lost my appetite to a degree that worries me when I think about it for too long.

I have gained sixteen pounds anyway.

This is exactly how it started with Mom.

Year five of Lexapro, she gained 38 pounds in eleven months. I watched what she ate. Oatmeal for breakfast. Salad for lunch. Grilled fish and vegetables for dinner. Smaller portions than mine. She was maintaining 1,200 calories a day with the dedication of a monk and her body was adding a pound a week.

Her doctor said: "It's a known side effect of the SSRI. We can try to manage it. Try eating less."

She cut her portions in half. Gained another twenty pounds.

I remember my father suggesting — not meanly, just confused — "Maybe you're snacking when no one is looking?"

She did not speak to him for three days.

One morning that summer I came over to drop off a casserole and I found her in the upstairs bathroom. She was standing at the mirror in a robe, pinching the skin on her stomach. Not crying. Just staring.

When she saw me, she said quietly, "I haven't eaten all the pies. Why does everyone think I ate all the pies?"

My mother at the upstairs mirror that summer
I found her in the upstairs bathroom that summer. She was pinching the skin on her stomach in the mirror. Not crying. Just looking.

I am 51 years old. I am 5'6". I am gaining a pound every four days, on 1,200 calories.

And the doctor wants to put me on the medication my mother took while this exact thing happened to her.

March 25

The hair.

I am finding it on my pillow. I am finding it in the shower drain. I am finding it on the back of my office chair. I am finding handfuls of it in the bathroom sink after I brush.

Yesterday I sat in my car in the parking lot of a wig shop in Indianapolis for twenty-two minutes before I drove away. I had pulled up there because I had Googled "natural-looking hairpieces for women with thinning hair" at 3 AM and one of the top results was that shop, two hours from my house, and I had told my husband I was running errands.

I sat there.

I cried.

I drove home.

I am 51 and I am researching wigs.

My mother was 56 when she started wearing scarves indoors. Then wider scarves. Then a hat at family dinners. By 58 she would not let me see her without something covering her head, not for two years, until the day her wig slipped at Thanksgiving and I saw her scalp for the first time. There were patches you could count the individual strands on.

"Dermatologist says it's hormonal," she had said brightly, fixing the wig back into place. "She's putting me on another pill."

Five years before she died, she did not own a single photo of herself with her own hair.

March 28

My husband found me at the kitchen table at 3 AM.

The laptop was open. Research articles on every tab. Patient forums. Medical journals. A notebook full of things I had been writing down for four nights in a row.

"Diane. What are you doing?"

"Research."

He sat down next to me. Read the screen for a long minute.

I had been on a thread of women describing my mother.

The kitchen table at 3 AM
Four nights in a row at the kitchen table. Research articles, patient forums, a notebook I had filled in two days.
Patient Forum · Replies (847)

I've been on antidepressants for nine years. My mood is fine. But I'm so tired I can barely function. I lost my job because I kept calling in sick. Nobody believes me when I say I can't get out of bed. They think I'm depressed and lying about it. But I'm not depressed. I'm empty.

Gained forty pounds in menopause. Eating less than my husband. Doctor says it's hormones. Hormones have been fine for six years. I'm still gaining.

I'm 58. My mother died at 71 having spent her last fifteen years too tired to leave the house. Her doctors said her mood was stable. Her labs were fine. They couldn't explain why she was disappearing. I'm watching the same thing happen to me. And no one will tell me what's wrong.

My husband looked at me. "These women… they sound exactly like your mom."

"I know."

"But their doctors say everything is fine."

"I know."

"So what's happening to them?"

I shook my head. "I don't know. But I'm not filling that prescription until I figure it out."

April 2

I found something tonight.

I had been searching the wrong things for weeks. Depression. Menopause. Weight gain. Hair loss. Fatigue. The internet kept giving me the same five answers and they were all answers I had already rejected because they had not saved my mother.

Tonight I searched something I had never searched before. I typed: why does treatment for depression not work for some people.

The first result was a medical journal. The sentence that stopped me was this:

"Persistent fatigue, weight gain, cognitive decline, and physical deterioration in depressed patients on standard treatment is frequently attributed to the depression itself or to medication side effects. Underlying cellular metabolic dysfunction — driven by chronic stress, elevated cortisol, and progressive depletion of mitochondrial NAD+ — is rarely investigated, despite emerging evidence that it is the central physiological feature of treatment-resistant cases."

I read that sentence three times.

Underlying cellular metabolic dysfunction.

Driven by chronic stress.

Progressive depletion of mitochondrial NAD+.

The central physiological feature of treatment-resistant cases.

I had no idea what NAD+ was. I had never heard the word mitochondrial spoken outside of high school biology. I sat there at 3 AM with a notebook and started writing.

April 3

I couldn't sleep. I went back to the laptop at 5 AM.

NAD+ is a coenzyme. It stands for nicotinamide adenine dinucleotide. Every single cell in your body uses it to convert food into energy. Without it, your mitochondria — the little engines inside every cell — cannot make ATP, which is the actual currency your body runs on. No ATP, no energy. No energy, no function.

Here is the part that made me sit up straight.

NAD+ levels in the human body decline by approximately 50% between the ages of 20 and 50. They keep declining through the sixties. By 70, you are running on about a quarter of what you had at 25.

And the rate of decline is not steady. It accelerates under chronic stress.

Cortisol — the stress hormone — burns through NAD+ at an elevated rate. The longer your cortisol stays high, the faster your NAD+ collapses. Chronic stress doesn't just feel like it's aging you. It is, at the cellular level, doing exactly that.

50%
decline in NAD+ by age 50

Here is what was beginning to take shape in my head at 5 AM at a kitchen table in March:

Depression causes chronic stress. Chronic stress raises cortisol. High cortisol burns through NAD+ faster than aging alone would. Low NAD+ starves your mitochondria. Starved mitochondria can't make energy. Without energy, every cell in your body begins to fail. The fatigue gets worse. The fog gets worse. The weight gets worse. The body falling apart makes you more depressed. The depression keeps the stress elevated. The cortisol keeps burning through whatever NAD+ you have left.

It's a loop.

A self-feeding, self-accelerating, twelve-year loop.

An antidepressant can lift your mood scale from a 4 to a 7. It can. It does, for many people, and I am not here to argue with anyone who has been helped by one. But an antidepressant does not raise NAD+. It does not slow the cortisol burn. It does not refuel the engine inside every cell of your body.

So while your mood scale climbs from a 4 to a 7, the engine keeps emptying.

You are stable on paper.

You are disappearing in the mirror.

April 4

I went down the rabbit hole.

If NAD+ collapse was the engine of the decline I had watched in my mother — and the engine of what was happening to me now — what else did it cause?

I searched: low NAD+ symptoms in women over 40.

Clinical Review · Published 2023

Persistent fatigue despite adequate sleep. Stubborn weight gain unresponsive to dietary modification. Cognitive decline, brain fog, word-finding difficulty. Hair thinning and accelerated greying. Loss of skin elasticity. Slow recovery from injury or exertion. Loss of lean muscle mass. Reduced exercise tolerance. Non-restorative sleep. Mood instability and anhedonia.

I sat back from the laptop.

Mom's decline didn't appear all at once. It appeared in sequence.

Year 1: Started Lexapro. Tired all the time.

Year 3: Stopped book club. Stopped church. Always tired.

Year 5: Gained 38 pounds eating less than my father.

Year 7: Hair falling out. Started wearing scarves.

Year 8: Couldn't remember names.

Year 9: Slept twelve hours and woke exhausted.

Year 10: Skin like paper. Bruises lasting a month.

Year 11: Stopped driving at night. Then stopped driving at all.

Year 12: Wouldn't get out of bed.

One after another after another. Like dominoes.

I had spent fifteen years thinking of Mom's decline as ten different problems with ten different specialists writing ten different prescriptions.

What if it was one problem?

What if it was a single molecule running out, in every cell, while six different doctors looked at six different symptoms and never once looked at the engine?

What if her cortisol stayed high the whole time — work stress, then loss-of-job stress, then weight-gain stress, then hair-loss stress, then becoming-unrecognizable-to-herself stress, then watching-everyone-look-at-her-with-pity stress — and her NAD+ burned faster every year because the depression and the loop and the cortisol kept feeding each other?

Six specialists. Twelve years.

Not one of them tested her cellular energy. Not one of them measured her NAD+. Not one of them asked the question I was asking at 5 AM in a kitchen in Indiana.

There wasn't even a routine clinical test for it.

April 5

Here is what I think happened to my mother.

She was 54 the year my father had his heart attack. He survived. She did not.

I don't mean she died. I mean something inside her broke that summer and never came back.

The stress of caregiving for a man who had nearly died, while raising the last of us through high school, while running the small accounting practice she had built for twenty years — that stress was the largest cortisol exposure of her adult life, and it lasted three years.

By the time my father was fully recovered, my mother had developed what her doctor would call a "depressive episode." She started Lexapro at 56.

Her mood stabilized on the medication. She was very clear about that. She said it often.

And under the stable mood, her body kept paying the cortisol bill from those three years.

Her NAD+ had already crashed by the time she started the antidepressant. The medication addressed the symptom. It did nothing about the engine.

So the engine kept emptying. For twelve more years.

Of course it cascaded.

A stable mood does not mean a stable body. It means one number on one questionnaire is in the range a doctor wants it in. Those are different things.
April 8

I am showing symptoms now.

Not just the depression. The whole pattern.

Recovery: I went on a thirty-minute walk last Sunday and my legs were sore for four days. Four days for a thirty-minute walk.

Brain fog: I forgot where I parked at the grocery store yesterday and wandered the lot for nineteen minutes. Three weeks ago I forgot the word for "spatula" at my own kitchen counter and stood there for a full minute staring at it.

The weight: still climbing. The hair: still on the pillow. The fog: still behind my eyes when I wake up at 6 AM after nine hours of sleep.

This is exactly how it started with Mom.

Year seven, she could not remember her grandchildren's names. They sent her to a neurologist. He talked about early dementia.

It wasn't dementia.

Her cells couldn't make energy.

And nobody checked that.

I am on the same path. And I have her diagnosis in my hand, my doctor's pen on the prescription pad, and a nurse calling me every three days to ask why I haven't started.

April 12

I went looking for NMN.

NMN — nicotinamide mononucleotide — is the direct biochemical precursor to NAD+. You take it. Your body converts it. Your NAD+ goes back up.

It is not a drug. It is a molecule your body makes a small amount of on its own from food. The supplement is just a concentrated source of the same molecule, in the dose required to make a measurable difference.

I read the research first. Harvard's Sinclair lab has been publishing on NMN for over two decades. There is a 2021 paper in the journal Science on postmenopausal women — the exact demographic of women in those forum posts, the women like my mother — who took 250mg of NMN a day for ten weeks. By the end of the trial, their muscle insulin sensitivity had returned to that of women twenty years younger. The cellular machinery that had been shutting down for thirty years switched back on. In ten weeks.

I ordered a bottle. Amazon. Top rated. 4.4 stars. 9,000 reviews. 1000mg per serving.

Started taking it Monday.

May 24

Six weeks on the NMN.

Nothing has changed.

Still exhausted. Still gaining weight. Still foggy. Still no recovery.

Wasted six weeks.

Ordered a different brand. Smaller company. More expensive. Maybe that matters.

July 19

Eight more weeks. Still nothing.

I don't know what else to do. My follow-up appointment is in twelve days. The doctor's nurse has called four times.

Every morning I wake up exhausted. Every time I forget something. Every pound I gain. Every strand of hair in the shower drain.

I see Mom.

Year 1: Started medication. Tired all the time.

Year 3: Stopped going out.

Year 5: 38 pounds heavier.

Year 7: Hair covered.

Year 10: Couldn't think.

Year 12: Wouldn't get out of bed.

I'm on Year 1.

What comes next?

July 27

Something happened today.

I was in Whole Foods. The supplement aisle. Standing in front of all the NMN bottles. Two of them I had already tried. Fourteen weeks combined. Zero results.

I was about to walk away. I did not have money to waste on another bottle that was not going to work.

Two women were talking one aisle over. An older woman, mid-sixties maybe, talking to a younger one. The older woman had a name badge on. It said "Certified Nutritionist."

I heard her say: "— it's not that NMN doesn't work. It's that most of what's on these shelves isn't actually NMN. There was an independent lab test in 2021. They tested twenty-two of the top-selling NMN brands on the market. Fourteen of them had less than 1% of the NMN they claimed on the label."

I froze.

One percent.

I walked around the corner. "I'm so sorry — what did you just say?"

She turned to me, completely unfazed, like she was used to women appearing out of nowhere asking her questions in the supplement aisle.

"NMN is delicate," she said. "Heat destroys it. Light destroys it. Moisture destroys it. The cheap brands are produced in huge batches with no temperature control, then sit in warehouses for months. By the time you swallow them, there's barely any NMN left. You're paying for inert white powder."

My chest tightened. "I've been taking NMN for three months. Two different brands. Nothing changed."

"Probably the wrong NMN. What are you taking it for?"

I told her. Not all of it. Just the outline. My doctor wanted to put me on Lexapro. My mother had taken Lexapro for twelve years while her body had quietly fallen apart. I had been reading about NAD+ and cellular energy and the stress loop. I had tried two brands. Neither had worked.

Her face changed. The polite professional warmth softened into something else.

"And nobody ever tested her NAD+."

"How did you —"

"They never do. They measure mood. They measure hormones. They prescribe based on what those numbers say. But none of those tests look at whether your cells can actually make energy. That's a different system entirely. It runs on NAD+. And NAD+ collapses with age — faster under chronic stress. Especially in women your mother's age. And in women yours."

She knew. Someone finally knew.

"So the antidepressant didn't cause my mother's decline."

"No. But it didn't prevent it either. Because NAD+ depletion was the root problem. The medication treated a symptom that was a downstream effect of cellular exhaustion. It didn't restore what her body actually needed to function. And here's the harder part — the depression itself was keeping her cortisol elevated. The cortisol was burning through whatever NAD+ she had left. The loop closed in on her every year a little tighter."

I couldn't breathe.

"How do I get real NMN? I just told you. I tried two brands."

"The clinical studies used pharmaceutical-grade NMN. Ninety-nine percent purity. Verified by HPLC testing. Most of what you can buy isn't that. It's cheap. It's fast. It's often inert by the time you take it. You're swallowing a tablet of dust."

She pulled out her phone.

"Only one brand I trust at this point. It's called Pria. Pharmaceutical-grade. 99% purity. Third-party HPLC tested for every single batch. Certificate of Analysis published on their website. You can verify what's actually in the bottle before you buy it."

I stood there in the supplement aisle. Certificate of Analysis. Third-party testing. Verified potency. Not "NMN" on a label with no standards.

"How do I know it actually works?"

"The real stuff, you'll feel a subtle lift within the first hour. Not a stimulant kick. A clarity. That's your blood NAD+ rising for the first time in maybe twenty years. Then over the next three to four weeks, symptoms start to shift. Recovery. Energy. Mental clarity. Weight starts moving. Sleep starts restoring. If your cells have been starving for fuel, giving them fuel changes everything else."

Within an hour. I would not have to wait six weeks wondering.

I pulled out my phone. Standing in that aisle at 4:18 PM on a Wednesday afternoon, I went to trypria.com and ordered it.

The brand the nutritionist sent me to
Pria NMN bottle

Pria — Pharmaceutical-grade NMN, 99% pure, third-party HPLC tested.

1,000mg per serving. Manufactured in a cGMP-certified facility in the United States. Certificate of Analysis published online before you ever buy. 90-day satisfaction guarantee — if it doesn't work, they refund you. No questions.

See if it's in stock →

They third-party test every batch before it ships, so it sometimes sells out between batches.

July 29

The bottle arrived this morning.

I opened it at the kitchen table. The capsules were clean white. No fillers. No additives. Just two small white capsules sitting in my palm.

I took them with breakfast at 8:30 AM. Drank my coffee. Sat at the table. Waited.

I had been disappointed too many times. I was not expecting anything.

8:47 AM: nothing.

9:02 AM: nothing.

9:17 AM: something shifted.

I do not know how else to describe it. A clarity. Like someone had wiped a film off the inside of my head.

It was not a stimulant kick. Not a buzz. Not a drug. It was as if the fog that had been sitting behind my eyes for two years — the heaviness that made every thought feel like it had to push through wet cotton — had thinned. Not gone. Just thinned.

I stood up. Walked into the bathroom. Looked at myself in the mirror.

My face was different.

The gray under my eyes was not as dark. The skin around my jaw was not as slack. I do not know whether someone else would have noticed it. But I noticed it.

I stood there for a long time.

At 9:55 AM I checked again. The clarity was still there.

I sat down on the edge of the bathtub and cried, very quietly, for about three minutes. Not from sadness.

From the feeling of someone giving back something I had stopped believing I would ever have again.

August 5

One week.

I woke up at 6:30 this morning. The alarm hadn't gone off yet. I just woke up.

I opened my eyes. I sat up. I got up.

I did not lie there for an hour willing my body to move. I did not hit snooze five times. I did not sit on the edge of the bed for a full minute working out how to stand.

I just got up.

My husband noticed. "You're up early."

I couldn't explain it. I had not slept more than usual. I was not more rested. But getting out of bed did not feel impossible anymore.

I made breakfast. I took a shower. I got dressed.

I did not need to rest between each task.

August 12

Two weeks.

I have lost three pounds. I have not changed anything I am doing. Same food. Same activity. I just lost it.

And I went for a walk yesterday. Twenty-five minutes. Around the neighborhood.

I did not crash. I did not need to sit down. My legs did not feel weak or shaky.

I came home. Made dinner. Did not lie on the couch for two hours afterward.

I think I can exercise again.

August 19

Three weeks.

I was in a meeting at work today. Someone asked me a question.

I answered it immediately. A full, coherent answer. I did not lose my train of thought halfway through. I did not have to ask them to repeat it. I did not have that cotton-wrapped feeling in my brain that has been there for nine months.

Later, I realized — I had not forgotten where I parked that morning.

I had not walked into a room and forgotten why.

I had not lost my train of thought mid-sentence.

The fog is lifting.

A morning meeting in August
A meeting I had been dreading for two weeks. I answered the first question without stumbling. I had not done that in eleven months.
August 26

Four weeks.

I ran my hand through my hair in the shower this morning. Maybe fifteen strands came out. Maybe ten.

Not forty. Not handfuls.

Just… normal shedding.

I checked the drain. Almost nothing. I checked my pillow. One or two strands.

My hair is still thin. Still finer than it used to be. It is not going to grow back overnight.

But it is not falling out in handfuls anymore.

And the skin on my face is different. The texture is finer. The dullness that has been there for two years is gone.

I looked at myself in the mirror this morning, in the kind of soft early light I usually try to avoid, and I saw myself again.

Not my mother. Myself.
September 1

I called my sister tonight.

"I can think clearly again," I told her.

Silence on the other end.

"Diane… how?"

I explained everything. The NAD+ connection. The stress loop. Why the Lexapro would have managed the mood and let the body keep falling apart. Why Mom kept declining even with stable scores. The processing methods that destroy most NMN supplements. The 14-of-22 lab study. The Certificate of Analysis. The difference between pharmaceutical-grade and inert white powder.

"I felt it working within 47 minutes," I said. "First dose. A clarity. Then over the next four weeks — energy came back. Lost six pounds. Brain fog lifted. I can exercise again. Hair stopped falling out."

Her voice cracked. "If this works — if you don't end up like Mom —"

"It's working. I promise."

"I'm ordering it," she said. "Tonight."

September 8

Follow-up appointment today.

The nurse took my blood. Checked my weight. Down seven pounds since March.

Dr. Roberts came in. Pulled up my results on her tablet. Looked at the screen. Scrolled. Frowned. Scrolled again. Looked at me.

"Diane. Your mood scale is a 7."

Silence.

"Up from a 4. Without medication."

She waited for me to explain.

I told her. Pharmaceutical-grade NMN. 99% purity. Third-party HPLC tested. Certificate of Analysis published online.

"Cellular energy was the missing piece," I said. "Once my NAD+ started coming back up, my body could actually function again. And once my body could function, the mood started following the body. The loop was running the wrong direction for a year. Now it's running the right direction."

She typed notes. Nodding slowly.

"Your symptoms?"

"Better. Sleeping through the night. Lost seven pounds. Brain fog is gone. Recovering from walks in a day instead of four. Hair stopped falling out. I can exercise without crashing."

She closed the tablet. Looked at me for a long moment.

"Whatever you're doing, continue. Your scores are improving without medication. We'll recheck in three months. If this trend continues, we may not need the Lexapro at all."

May not need the Lexapro.

No twelve years on a medication while my body fell apart underneath a stable mood score.

No cascade.

No wheelchair.

I walked to my car. Got in. Sat there.

Then I called my husband.

"Mood score is up to a 7. Symptoms are better. No medication."

I heard him exhale on the other end. Then his voice broke.

"Thank God. Diane, I was so scared you would —"

"I know. Me too."

Today

It has been a little over eight weeks since I started the real NMN.

Mood scale: 8. Energy: back. Weight: down ten pounds. Skin: different. Hair: holding. Memory: back. Recovery: back.

No medication.

No following my mother's path.

No Year 3 stopping going out. No Year 5 gaining 38 pounds. No Year 7 covering my hair. No Year 10 losing my words. No Year 12 unable to leave a bed.

I went hiking with my daughter yesterday. Four miles, up a mountain trail in the southern part of the state. I carried a backpack.

I did not get winded.

At the summit with my daughter
At the summit with my daughter. The first hike I have done in two years. I carried the pack.

At the summit she pulled me into a hug. "Mom. You did it. Can we do this every weekend?"

My throat tightened. My eyes burned.

Because the answer was yes.

And because I thought about my mother. Who never got to say yes. Who spent twelve years too tired to hike, too heavy to climb, too foggy to remember, too broken to recover — while her mood was stable the whole time.

I am not following her path.

I found the exit before the trap closed.

What I know now.

A stable mood score does not mean your body is working. It means one number on one questionnaire is in the range a doctor wants it in. Those are different things.

Depression and chronic stress drive a cellular energy crisis that no antidepressant addresses. Your cortisol stays high. Your NAD+ burns down faster than aging alone would burn it. Your mitochondria can't make energy. Your body starts to fall apart — fatigue, weight, fog, hair, skin, sleep — and the falling-apart makes the depression worse, which keeps the cortisol high, which keeps the NAD+ burning down.

This is the loop. It's why so many women — and men — describe feeling "stable but disappearing." Stable on the mood scale. Disappearing in the mirror.

Aging isn't random decline. It cascades. NAD+ collapses. Cellular energy collapses. Then your muscles weaken. Then your brain slows. Then your skin sags. Then your immune system fails. Then your sleep stops restoring you. Then you stop wanting to leave the house. Then your mood follows the body down.

Standard medical protocols do not measure NAD+. Not because it does not matter. Because there is no easy clinical test for it yet, and no insurance code for it.

Most NMN supplements are degraded by the time you take them. Heat, light, moisture, time. You are paying for inert powder.

The version that works — pharmaceutical-grade, 99% pure, third-party HPLC tested, Certificate of Analysis published — you can verify before you buy.

You will feel it working within an hour. The clarity. Proof the NMN reached your bloodstream.

Then over weeks: symptoms improve. Energy returns. Weight comes off. Brain fog lifts. Hair stops falling out. Recovery returns. Exercise becomes possible again.

Your mood improves. Whether you are on medication or not.

Because you restored the engine.

I am writing this for the people who might be reading.

If your doctor wants to put you on an antidepressant. Or a sleep aid. Or another medication for menopause, or another one for your hair, or another one for the weight that will not move. And you are not sure that any of those is what is actually wrong.

If you are a woman in your forties or fifties or sixties — exhausted in a way no amount of sleep fixes, gaining weight on less food than your husband eats, watching your hair go down the shower drain, losing words mid-sentence, looking at your mother and seeing your own future.

If you are a man in your fifties whose wife has told you twice this year that you don't seem like yourself anymore — heavier than you should be, tired by 2 PM, foggy in conversations you used to lead, asleep on the couch by 8.

If you are a younger woman — thirty-five, forty — already feeling all of this and being told it is "just stress" or "just being a working mom" or "just where things are these days."

If you have already been on an antidepressant for a year, two years, five years, and your mood is "fine" but your body has been quietly emptying out underneath you.

If you have tried HRT, supplements, therapy, diets, sleep schedules, gratitude journals — and you are still tired, still gaining, still foggy, still disappearing.

You are not lazy. You are not weak. You are not making it up.

Your cells are running out of fuel.

And there is a way to refuel them.

The brand I trust — and the one I keep recommending
Pria NMN three-bottle bundle

Real NMN. Real results. Or your money back.

Pria delivers 1,000mg of pharmaceutical-grade NMN per serving — verified at 99% purity by third-party HPLC testing for every single batch. Made in the USA in a cGMP-certified facility. Certificate of Analysis published openly on their website. A 90-day satisfaction guarantee, no questions asked.

Check if Pria is in stock →

If you've been disappearing in a body your doctor calls "fine" — start with a single bottle. You'll know within an hour whether it's real.

— Diane
Bloomington, Indiana · January 2026

P.S. — I went back through the receipts the other night. Before I found Pria, I had spent about $1,400 over six months on things that did not work. HRT cream. A patch. Maca root. Ashwagandha. A "women's libido blend." Probiotics. Couples therapy. Two NMN brands that were almost certainly inert. The bottle of Pria that actually worked was $79.

P.P.S. — If you click the link and Pria is sold out, they are not gone. They simply third-party HPLC test every batch before it ships, and the testing takes time, so they sometimes run out between batches. I would still click the link and check, because if there is inventory and you are where I was in March, I would not wait.

P.P.P.S. — I never filled the Lexapro prescription. It is still in a drawer in my kitchen. I keep it there as a reminder of how close I came to writing a very different version of this story.