Men's Health November 18, 2025

At 45, I stopped feeling like myself. Three doctors couldn't figure out why. A podcast on a back road in Texas finally did.

I spent two years getting bloodwork, trying every supplement on Amazon, and being told I was "in excellent health." Then I heard one sentence on a podcast that explained everything.

Steven Brooks
Steven Brooks
Reader Contribution · Verified Pria Customer
9 min read

The photo my wife sent me. Taken at our vacation last summer. I didn't recognize the man on the right.

My wife sent me a photo from our last vacation about eight months ago. She didn't mean anything by it. She was just sharing a memory.

But I sat there at my desk staring at this picture of a tired, soft, slightly hunched man with my face, and I thought: when did I become him?

I'm 45. I sleep eight hours a night. I haven't had a drink in two years. I lift weights three times a week. By every metric my doctor uses, I'm in excellent shape.

But I'd been faking it for about two years. Faking it in meetings I used to dominate. Faking it with my wife at the end of the day. Faking it with my son who'd stopped asking me to play catch because daddy was always "just going to sit for a minute."

This is the story of what I found when I finally stopped pretending and started looking.

• • •

The things I didn't say out loud.

I made a noise when I got out of the car. Just a small one — a kind of involuntary grunt. I never used to make a noise.

I sat on the edge of the bed for a minute before I stood up in the morning. Not because I wanted to. Because I had to.

My wife and I hadn't been intimate in five weeks. She hadn't said anything. I hadn't said anything. It had just slowly become a thing we both stopped initiating.

I cancelled a fishing trip with my brother last spring because the drive felt like too much. He's 49. He didn't say anything either. He just said "next time."

There was no next time. I could feel it. I was 45 and becoming a man my own kids would tolerate but not look up to. The worst part wasn't that it was happening. The worst part was that I'd been pretending it wasn't.

I was 45 and becoming a man my own kids would tolerate but not look up to. And I'd been pretending it wasn't happening.

The Saturday it broke me.

My son had a soccer game. He's seven. Afterwards he wanted to kick the ball around in the backyard.

I told him "in a minute, buddy, daddy just needs to sit down for a second."

I fell asleep on the couch.

When I woke up two hours later, he was in the living room watching TV by himself. He didn't say anything. He didn't seem upset. He'd just figured out that daddy wasn't coming.

I sat there on the couch and thought about how many times this had happened in the last year. How many "in a minutes" had turned into "maybe tomorrows." How many tomorrows I'd already burned through without noticing.

That's the night I started looking for actual answers.

• • •

Why bloodwork keeps coming back "fine" when you feel like hell.

I'd already done the responsible thing. I'd been to three different doctors in 18 months. Same answer each time. Testosterone in range. Thyroid fine. B12 fine. Cholesterol fine. One of them suggested I "try meditating."

I'd already done the rest. Cut alcohol — barely moved the needle. Added cardio — made the fatigue worse. Tried keto for six weeks — felt strong for a month, then crashed harder. Magnesium glycinate. Ashwagandha. Creatine. A multivitamin that cost $80 a bottle. I even bought a cheap NMN bottle off Amazon because I'd heard Joe Rogan mention it on a podcast.

Three months. Nothing.

What I learned later: there's one number that explains everything, and it's not on any standard blood panel.

Your Cellular Energy Drops By Half After 40
NAD+ levels by age — measured against your 25-year-old baseline
100% Age 25 Baseline 80% Age 35 Slight decline 50% Age 45 The wall 33% Age 55 One third left 22% Age 65 Critical
At age 45, your cells are running on half the energy you had at 25. That's why workouts feel harder, recovery takes longer, and 2 p.m. flattens you — even when your bloodwork comes back "normal."
Sources: Massudi et al., PLOS ONE 2012 · Yoshino et al., Science 2021

The one number no one tests.

I was driving home one night listening to Andrew Huberman's episode on something called NAD+, and I had to pull into a gas station parking lot to take notes on my phone. Everything he described was happening to me. Every single thing.

Here's what I finally understood.

Every cell in your body runs on a coenzyme called NAD+. It's the molecule your cells use to make energy, repair DNA, and keep you running the way you did at 30. By the time you hit your mid-40s, your NAD+ levels have dropped by more than half. By 55, you're at roughly a third.

That's why workouts feel harder doing the same routine. That's why 2 p.m. flattens you. That's why your recovery takes four days instead of one. And here's the part that made me grip the steering wheel:

Your doctor doesn't test NAD+. It's not on any standard blood panel. So you can be tanking on a cellular level and your bloodwork comes back "fine" and your doctor tells you to meditate.

Late evening reflection

Most of my evenings looked like this. I was 45 and I'd already given up on the day by 7 p.m.

Dr. David Sinclair at Harvard Medical School has been studying this for fifteen years. He takes a specific protocol every morning — NMN, TMG, Trans-Resveratrol. At 55, his biological age markers come back in the early 30s. Bryan Johnson, the guy who spends $2 million a year reverse-engineering aging, takes the same core stack. Joe Rogan started taking it after he interviewed Sinclair.

I sat in that gas station parking lot for forty minutes reading everything I could find.

The hard lesson I learned about Amazon NMN.

Remember that cheap NMN bottle I'd bought off Amazon? The one that did nothing for three months?

In 2021, a Harvard-affiliated lab tested 22 NMN products on the market. They published the results in a paper titled "Quantitative Analysis of Twenty-Two NMN Consumer Products."

The findings:

2021 ChromaDex Analysis · 22 NMN Brands Tested
14 of 22 brands
Under 1% real NMN content
3 of 22 brands
Zero detectable NMN — rice flour
5 of 22 brands
Contained the NMN they claimed

I'd probably been swallowing rice flour for three months.

And there was another problem. Even when the NMN is real, it's only one part of the protocol. The Sinclair-style stack has four ingredients that work together:

  • NMN — to rebuild NAD+ from the precursor
  • TMG — to replace the methyl groups NMN burns through (skip this and you burn out)
  • Trans-Resveratrol — to activate the longevity genes (sirtuins) the NAD+ is meant to fuel
  • Apigenin + Quercetin — to slow CD38, the enzyme that destroys NAD+ as you age

Take NMN alone and you're driving with the parking brake on. The cheap Amazon NMN, even if real, would have done a fraction of what the full stack does.

I didn't want four bottles. I didn't want a regimen. I wanted one capsule made by people who actually publish what's in it.

If you're at the part of this where you want to know what I actually started taking — I'll get there in a minute. Or you can jump ahead.

→ See what I'm taking (and why I'm still on it)

The first thing I tried that actually worked.

I found Pria. The reason it stood out from the other brands I'd been comparing came down to four things I'd been told to look for after reading the ChromaDex paper.

What I Was Looking For
NMN Dose
1,000mg — top of the safety-tested range (MIB-626 trial went to 1,250mg)
Stack Complete?
10 ingredients including TMG, Trans-Resveratrol, Apigenin, Quercetin
Third-Party Tested?
≥99% HPLC verified every batch. COA published per batch number.
Made Where?
cGMP USA facility. NDI-acknowledged supplier (post-Dec 2025 reinstatement)

It came with a 30-day money-back guarantee. Even empty bottles accepted. I figured if it didn't work, I'd send it back and be out nothing.

Pria bottle on kitchen counter

Two capsules in the morning. That's the whole protocol.

What changed wasn't just physical.

I'm not going to lie about the first two weeks. Nothing happened. I almost gave up and almost asked for the refund.

Then around week three, I noticed I made it past 3 p.m. without the crash. Not gone — just pushed back. By week five I was waking up before my alarm again, actually rested.

But that's not really what I want to tell you about.

I want to tell you that my wife reached for me in bed for the first time in months and I didn't have to talk myself into it.

I want to tell you that I took my son out to the backyard last Sunday and we played until the sun went down and I was the one who suggested we go inside, not him.

I want to tell you that I caught myself in the mirror two weeks ago shaving and thought — not "I look great," I'm not going to oversell this — but "there he is. There's the guy I forgot was still in there."

I want to tell you that I called my brother last week and rebooked the fishing trip. And on the phone he said "you sound different." And he was right.

What Happened, Week by Week
Weeks 1-2
Nothing visible. Almost gave up. Sleep got slightly deeper but I didn't trust it.
Week 3
Made it past 3 p.m. without the crash for the first time in years. First sign of life.
Week 5
Waking up before the alarm, actually rested. No more dragging.
Week 8
Caught myself taking stairs two at a time. Gym recovery dropped from 4 days to 1.
Month 3
My wife asked what I was doing differently. She'd noticed before I'd said anything.
Month 6
Backyard catch with my son for 45 minutes. I didn't have to call it early.

I'm six months in. I don't feel 30. I feel 38. Sharp. Solid. Back in the gym five days a week. Recovery in a day instead of four. My wife touches my arm when I walk past her in the kitchen, which is a small thing nobody but a married man would understand. My son comes to find me in the evenings now because he knows I'll actually do something with him.

I got something back I didn't know how badly I missed until it was returned.

I wrote about this online. Hundreds of men wrote back.

I posted a version of this story on a longevity forum about three months ago. I expected maybe ten or twenty replies. What I got was three hundred and forty messages from men in their 40s and 50s who said variations of the same thing: "this is me." Here are three of them, lightly edited and shared with permission.

David
David, 51 — Texas

I'm a contractor. I work with my hands for a living. Three years ago I started having to take a break halfway through a roof job. I'm 51, not 71. My doctor told me it was just age. Eight weeks in on Pria and I'm finishing days that used to take me out cold. My wife asked me what I changed. I didn't even tell her at first — I wanted to see if she'd notice before I said anything. She noticed.

Robert
Robert, 47 — Ohio

I was the guy who used to outwork everyone at the office. Then I wasn't. Then I stopped being invited to things because I was always "tired." I'm not going to tell you my marriage was in trouble — it wasn't dramatic — but it had gone quiet. Six months on the stack and I feel like I'm meeting myself again. My wife and I went to the gym together last month for the first time in five years. That's the closest I can get to telling you what changed.

Mike
Mike, 53 — California

I'd tried Tru Niagen. I'd tried two different NMN brands off Amazon. I'd tried TRT — got my levels checked, doctor said I was in range, sent me home. Nothing did anything until this. Nine weeks in, my sleep is the deepest it's been since I was 35, my morning energy doesn't need caffeine to start, and I don't think about my age the way I used to. That's the part I didn't expect — I just don't think about it anymore.

Who I am again.

Here's what nobody told me about getting energy back at 45. It's not really about the energy.

It's about being the husband your wife thought she was marrying. It's about being the father your kids will actually remember instead of the tired man who said "in a minute" until they stopped asking. It's about looking at vacation photos and recognizing the man in them.

It's about not pretending anymore.

I'm not the guy I was at 25 and I don't want to be. That guy was an idiot. But I'm the guy I was at 35 again — the version of me who knew what he was doing, who could carry his weight, who his wife actually wanted to come home to. That guy was still in there. He just needed something my doctor wasn't going to give him.

That guy was still in there. He just needed something my doctor wasn't going to give him.
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You can. But here's what I learned the hard way: the first 30 days are the slowest. Nothing dramatic happens in weeks 1-2. The shift hits between week 3 and week 8. If you only have one bottle and you run out mid-shift, you either pay full price to continue ($59.99 instead of $19.99 per bottle), miss the free e-book, miss free shipping, or stop and lose the momentum. The 3-bottle at $19.99/bottle saves you $119.98 and gives you the full window to actually know.
Is the e-book actually any good or is it just filler?
It's the one I wish I'd had when I started. Dr. Hartman covers the four labs your doctor isn't running, the specific timing protocol most men get wrong, and what to expect at each milestone. 87 pages, no fluff. He sells it on his own site for $29.99. You get it free with any bundle.
What if it doesn't work for me?
Send it back. 30 days, empty bottle accepted, full refund. That applies to bundles too — finish the first bottle, return the rest unopened if you're not feeling it. The worst case is you lose 30 days. The best case is you get yourself back.

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This article reflects a verified Pria customer's experience. Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement, particularly if you take prescription medications or have a medical condition.